|MSM impacts osteoarthritis by reducing pain, inflammation, muscle spasm, and slowing cartilage degeneration. Initial benefits may be achieved with a relatively small intake of Gel-out© MSM. Take flakes at 5 grams (1 teaspoon) per day. Increase intake gradually for optimal benefit. The topical Gel-out© gel increases the potential for relief - especially with the addition of a heating pad for up to 30 minutes per application.