||Gel-out© flakes and Gel-out® gel have the potential to provide relief to chronic conditions. Whether benefit is rapid, or months in coming, MSM has been shown to provide a natural side-effect free option. Supplementation with Gel-out® flakes may need to be continued for longer periods, sometimes indefinitely. For consistent and more complete benefit, the dosage required may be increased. Utilize the gel two or three times daily to target specific areas. The addition of heat with the gel often provides additional benefits.